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Wellness Prevention

Common Side Effects of the Shingles Vaccination and How to Manage Them

Dr Edith Loo
Virtue Medical Content Team
Medically reviewed by Dr Edith Loo — Written by Virtue Medical Content Team — Updated on 16 December 2025
5 mins read

Key Takeaways

Shingles can be severely painful and more common after age 50, but vaccination greatly lowers your risk and helps prevent complications like long-lasting nerve pain. Most side effects are mild and short-lived (sore arm, fatigue, headache, low fever) and can be managed with rest, hydration, and simple pain relief—seek medical attention only if you develop severe or persistent symptoms.

The shingles vaccination is a key tool in protecting adults, particularly those over the age of 50, from developing shingles, a painful condition caused by the reactivation of the varicella-zoster virus (the same virus that causes chickenpox). 

While the vaccine significantly reduces the risk of developing shingles and its complications, like any medical intervention, it can cause side effects. Understanding these side effects and how to manage them can help individuals feel more confident about getting vaccinated.

What is Shingles and Why Should You Get Vaccinated?

Shingles, also known as herpes zoster, is a painful rash that typically appears on one side of the body or face. It can cause severe pain, burning, and itching, followed by blisters that eventually crust over. The condition is caused by the varicella-zoster virus, which remains dormant in the body after a person recovers from chickenpox. As people age, their immune system weakens, making it more likely for the virus to reactivate and cause shingles.

The shingles vaccination is designed to boost the immune system’s defense against the varicella-zoster virus, reducing the likelihood of an outbreak. It is particularly recommended for older adults, as they are at higher risk of developing shingles and experiencing its painful complications, such as post-herpetic neuralgia (PHN), a condition where pain persists even after the rash has healed.

Common Side Effects of the Shingles Vaccination

While the shingles vaccination is generally safe, some individuals may experience mild side effects. These side effects typically appear shortly after the vaccination and resolve on their own within a few days. The most common side effects include:

1. Pain at the Injection Site

One of the most common side effects of the shingles vaccination is pain at the injection site. This can include soreness, redness, or swelling where the vaccine was administered. The discomfort is usually mild to moderate and should improve within a few hours to a few days.

How to manage: To alleviate the pain and swelling, you can apply a cold compress to the affected area. Over-the-counter pain relievers, such as ibuprofen or acetaminophen, may also help reduce discomfort.

2. Redness and Swelling

Some individuals may notice redness or swelling at the injection site, which can last for a few days. This reaction is a normal part of the body’s immune response to the vaccine.

How to manage: Applying a clean, cold compress to the injection site can help reduce swelling and redness. If the swelling persists or becomes more severe, it’s advisable to consult a healthcare professional.

3. Fatigue

Feeling tired or fatigued after receiving the shingles vaccination is a common side effect. This fatigue can last for a day or two and typically resolves without medical intervention.

How to manage: Resting and staying hydrated are key to managing fatigue. If you feel very tired, consider taking naps and avoiding strenuous activities until you feel better.

4. Headache

Some individuals experience headaches following the shingles vaccination. These headaches are usually mild to moderate and should subside within a few days.

How to manage: Drinking plenty of water and taking over-the-counter pain relievers, such as acetaminophen or ibuprofen, can help alleviate headache pain. If the headache becomes severe or persists for more than a few days, it’s important to consult your healthcare provider.

5. Fever and Chills

A mild fever or chills may occur after receiving the shingles vaccination. This is a normal response as the body’s immune system reacts to the vaccine. The fever is typically low-grade and lasts for a short period of time.

How to manage: Taking an over-the-counter fever reducer, such as acetaminophen, can help lower the fever and relieve chills. Staying hydrated and resting are also important to help your body recover more quickly.

6. Muscle or Joint Pain

Some people may experience mild muscle or joint pain after receiving the vaccine. This discomfort is usually temporary and should resolve within a few days.

How to manage: Mild muscle or joint pain can be alleviated with over-the-counter pain relievers. Gentle stretching and resting can also help reduce discomfort. If the pain becomes severe or persistent, it’s important to reach out to your healthcare provider for further advice.

7. Nausea

Nausea is another less common side effect of the shingles vaccination. While it can be uncomfortable, it typically resolves within a short period after vaccination.

How to manage: To manage nausea, try eating small, light meals throughout the day. Staying hydrated is also important, and sipping ginger tea or drinking fluids like water or clear soup can help soothe the stomach. If nausea persists or is accompanied by vomiting, contact your healthcare provider.

Rare Side Effects of the Shingles Vaccination

While the side effects mentioned above are common and generally mild, there are some rare and more serious side effects that may occur. These are much less frequent and require immediate medical attention:

  • Severe allergic reaction (anaphylaxis): While extremely rare, some individuals may experience an allergic reaction to the vaccine. Symptoms of anaphylaxis include difficulty breathing, swelling of the face or throat, rapid heartbeat, and dizziness. If you experience any of these symptoms, seek emergency medical help immediately.
  • Rash or hives: Some individuals may develop a rash or hives as a result of the vaccination. If the rash is severe or accompanied by other symptoms, it’s essential to seek medical attention.

When to Seek Medical Attention

While most side effects of the shingles vaccination are mild and temporary, it’s important to seek medical attention if you experience any of the following:

  • Severe allergic reactions (difficulty breathing, swelling, or dizziness)
  • A rash that appears outside the injection site or is accompanied by other symptoms
  • A persistent fever lasting more than three days
  • Severe or prolonged headache
  • Persistent pain or swelling at the injection site

If you’re concerned about any side effects or if they don’t improve within a few days, contact your healthcare provider for guidance.

Tips for Reducing the Risk of Side Effects

There are a few strategies you can implement before and after getting the shingles vaccination to help reduce the likelihood or severity of side effects:

  • Stay hydrated: Drink plenty of fluids before and after the vaccination to help your body manage the immune response and prevent dehydration from fever or chills.
  • Rest: Ensure that you get enough rest both before and after the vaccination. Adequate sleep will help your body’s immune system function optimally.
  • Over-the-counter pain relievers: If you anticipate any pain or discomfort after the vaccination, consider taking over-the-counter pain relievers, like ibuprofen or acetaminophen, as recommended by your healthcare provider.
  • Cold compress: Applying a cold compress to the injection site can help reduce swelling, redness, and pain.

Conclusion

The shingles vaccination is an effective way to protect against shingles, a painful and debilitating condition that can cause long-term complications. While the vaccine can cause mild side effects like pain at the injection site, fatigue, and fever, these are typically temporary and manageable. 

By understanding these side effects and how to handle them, you can better prepare yourself for the vaccination and ensure a smoother recovery.

If you’re considering shingles vaccination or have concerns about potential side effects, don’t hesitate to discuss them with your healthcare provider. They can provide personalized advice based on your medical history and help ensure that you make an informed decision for your health and well-being.

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