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STD

Unexpected Signs of STDs: 10 Symptoms to Watch Out For

Dr Edith Loo
Virtue Medical Content Team
Medically reviewed by Dr Edith Loo — Written by Virtue Medical Content Team — Updated on 16 December 2025
5 mins read

Key Takeaways

STDs don’t always show up as obvious genital symptoms—fatigue, sore throat, rashes, joint pain, eye infections, urinary changes, and digestive issues can also be warning signs. If something feels “off” or you’ve had unprotected sex, an STD test gives clarity and helps prevent complications and onward transmission.

Sexually transmitted diseases (STDs) are often associated with common symptoms like genital sores, burning urination, or unusual discharge. However, some STDs present themselves in ways that may not immediately raise concern. 

Recognizing these unexpected signs is crucial for early detection and treatment. If you experience any of the following symptoms, getting an STD test can provide clarity and help prevent further complications.

1. Unexplained Fatigue

If you feel persistently exhausted despite getting enough rest, it could be more than just stress or a busy schedule. Some STDs, like HIV and hepatitis, can cause chronic fatigue as they affect your immune system and energy levels. 

This kind of fatigue is often accompanied by other symptoms like night sweats, fever, or swollen lymph nodes, but it can also appear on its own. If your exhaustion has no clear explanation, it might be time to get checked.

2. Sore Throat

While sore throats are commonly linked to colds and flu, they can also be an indicator of STDs such as gonorrhea and chlamydia when transmitted through oral sex. Unlike a regular sore throat that improves with rest and fluids, an STD-related sore throat may persist for weeks and resist typical treatments. If your sore throat lingers without other typical cold symptoms like a runny nose or congestion, it might be time for an STD test.

3. Joint Pain and Swelling

STDs like gonorrhea and syphilis can sometimes lead to reactive arthritis, causing joint pain and inflammation. This happens when the body’s immune system overreacts to an infection, leading to symptoms similar to arthritis. If you’re experiencing unexplained joint discomfort, stiffness, or swelling, it could be a sign of an underlying infection that needs medical attention.

4. Unusual Skin Rashes

Some STDs, particularly syphilis and HIV, can cause skin rashes that appear as red or brown spots on different parts of the body, including the palms and soles. These rashes may not be itchy, making them easy to overlook. Additionally, herpes can cause small, painful blisters on the skin, sometimes in areas beyond the genitals. If you develop a persistent rash that has no obvious cause, consider seeing a doctor.

5. Sudden Changes in Urination

While painful urination is a well-known symptom of STDs, conditions like chlamydia and trichomoniasis can also cause increased frequency, urgency, or changes in urine color. A burning sensation, cloudy urine, or blood in the urine could indicate an infection. Since these symptoms can also be related to urinary tract infections (UTIs), it is important to get tested to determine the underlying cause.

6. Eye Infections

Surprisingly, some STDs can affect the eyes. Chlamydia and gonorrhea can cause conjunctivitis (pink eye), leading to redness, irritation, and discharge. This happens when bacteria or viruses spread to the eyes through contaminated hands or other means. If you have persistent eye discomfort, swelling, or sensitivity to light without an apparent reason, an underlying infection could be the culprit.

7. Unexplained Weight Loss

Unintended weight loss, particularly when combined with other symptoms, could signal an STD such as HIV. This occurs due to immune system impairment and metabolic changes. Weight loss might be gradual or sudden, and it is often accompanied by loss of appetite, fever, or diarrhea. If you’re losing weight without changes in diet or exercise, consult a healthcare professional to rule out any serious health issues.

8. Digestive Issues

Some STDs, including HIV and syphilis, can lead to gastrointestinal symptoms like diarrhea, nausea, and abdominal pain. Infections can disrupt the normal function of the digestive system, causing persistent stomach discomfort. If digestive troubles persist without an obvious cause such as food intolerance or stress, consider getting tested for STDs.

9. Frequent Yeast Infections

Recurring yeast infections, particularly in women, can sometimes be linked to underlying STDs like HIV, which weakens the immune system and makes the body more susceptible to infections. If you experience frequent episodes of vaginal itching, thick discharge, or discomfort, it might be worth discussing with a doctor to rule out any underlying health concerns.

10. Neurological Symptoms

Advanced syphilis and HIV can lead to neurological issues such as memory problems, difficulty concentrating, headaches, and even numbness or tingling in the extremities. Syphilis, if left untreated, can progress to neurosyphilis, affecting brain function and mental health. If you’re experiencing these symptoms without a known cause, seeking medical attention promptly is essential.

The Importance of Regular Testing

Many STDs can remain asymptomatic for long periods, making regular testing essential for sexual health. If you have had unprotected sex or notice any of these unusual symptoms, scheduling an STD test can help you stay informed and protected. Early detection not only improves treatment outcomes but also prevents the spread of infections to others.

Who Should Get Tested?

It is recommended that sexually active individuals get tested regularly, especially if they have multiple partners, engage in unprotected sex, or have a partner with a known STD. Pregnant women should also consider testing, as some STDs can be passed to the baby during childbirth. Testing is straightforward and often involves a simple blood test, urine sample, or swab.

What to Expect During an STD Test

Getting an STD test can feel intimidating, but it is a routine procedure that healthcare providers perform daily. The type of test will depend on the symptoms and risk factors involved. Some tests require a blood draw, while others involve a urine sample or swab of the affected area. In most cases, results are available within a few days, allowing for quick diagnosis and treatment if necessary.

Preventing STDs

Practicing safe sex is the most effective way to reduce the risk of contracting an STD. Using condoms correctly, limiting the number of sexual partners, and maintaining open communication with partners about sexual health can significantly lower the chances of infection. Additionally, vaccinations for HPV and hepatitis B provide extra protection against certain sexually transmitted infections.

Seeking Medical Help

If you suspect you might have an STD, don’t hesitate to seek medical advice. Ignoring symptoms can lead to serious complications, including infertility, organ damage, or long-term health issues. Many STDs are easily treatable with antibiotics or antiviral medications when detected early. The key is to be proactive about your health and address any concerns promptly.

Conclusion

Understanding these unexpected signs of STDs can help you take proactive steps toward maintaining your health. Don’t ignore subtle symptoms—if something feels off, seeking medical advice is always a smart choice. Regular STD testing is a simple yet effective way to protect yourself and your partners, ensuring that any potential infections are caught and treated early. 

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